Introduction:

According to the World Health Organization (WHO), India would have around 57 million diabetic patients by the year 2025. Type 2 diabetes isthe most common form of diabetes. Diabetics has received a great deal ofattention in the novel drug delivery technologies because optimal and controldrug delivery is required in Diabetic disease.

In field of medical textile, there is no specific device ortechnologies which can act according to blood glucose level. In this technology,we are trying to develop the glucose sensitive interactive wears for borderlineType-II Diabetic patients.

In this project, we are trying to incorporate an optimal andcontrol drug delivery into the wear. In this technology, a potent herbal drugwill be delivered to the system by the optimal and control way. This technology is based on the reactionof glucose in the blood with glucose oxidase. This reaction can be immobilizedon polymers. The glucose/glucose-oxidase reaction causes a lowering of the pHin polymer Drug deliverys specific area. It can cause an increase in theswelling of the polymer drug delivery system, leading to an increased releaseof Anti-Diabetic herbal drug into the blood.

The polymers which are pH sensitive and degradable in anacidic environment can be used in this technology.

Methodology:

Step-1: Select the suitable acidic or basic polymer.

Characteristic:

• Acidic or basic polymer
• Bio degradable
• Non- toxic
• Bio- compatible to skin
• Regulatory approved
• Radiation stabilize

Step-2: Convert the acidic or basic polymer into hydrogel by radiationsynthesis.

Step-3: Drug characterization and Analysis

• Select the suitable drug
• Study the pharmacological properties of the drug.
• Pharmaceutical analysis

Step-4: Pharmaceutical formulation

It is the novel Transdermal drug delivery device

• Design the formulation
• Check homogeneity of the product
• Apply the uniform coating on suitable substrate.

Check for following things:

• The uniformity of the patch.
• The drug content
• Gel strength
• Moisture content
• Drug delivery rate
• Skin permeation rate

Step-5: Clinical testing of patch

Step-6: Incorporation of the novel Transdermal drug delivery device into T-shirt or shirt

• Calculate the drug release rate in one centimeter square area.
• Then make the suitable size patches according to patients needs.
• Study the contact points of shirt to the body and also area of contact
• Then design the patch
• Laminate the patches on T-shirt or shirt with PSA hooks and loops.
• The patches can be worn for 3-5 days.

Mechanism of Action:

The technology is based on the reaction of glucose in the blood with glucose oxidase. This reaction can be immobilized on polymers. The glucose/glucose-oxidase reaction causes a lowering of the pH in the polymer which causes an increase in the swelling of the polymer, leading to an increased release of Anti-Diabetic herbal drug into the blood.

Benefits of Glucose Interactive wears:

• Freedom from an oral drug delivery.
• A needle free Painless technology
• Controlled release of drug.
• Steady blood-level profile.
• Reduces Systemic Side Effects.
• By-passes the first phase hepatic metabolism so reduces gastric troubles.
• User-friendly and convenient.
• Improves the patient compliance.

Conclusion

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